When I ran a room instead of the cabinet that I use now, I ran 'em sealed. Why?....I liked the simplicity and less expense of not having all the fans/ductwork. Secondly, I always found it easier to control temp and humidity with A/C as opposed to more intake and more exhaust movement. One last thing to consider....if you set it up as a sealed room and don't like it after a grow or two, cutting holes and adding ventilation is somewhat easier that patching them back up to go from vented to sealed. Juss my opinion, others results will vary.
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