Pruning, fiming/toppinng, and supercropping can be very stressful for the plant, but helpful for yield and quality. Different plants in different environments can handle different amounts of stress... With that said, I say go for it, if your plants seem healthy. I would probably prune the bottom 1/3 of the plant and any inner leaves that are shading bud sites depending on your grow style(SOG,SCROG etc). Especially if it is a sat/sat dom. I assume your scrog or sog w/T5. The T5 lighting probably is not going to penetrate more than 2' in the end (more like 1.5'). So you need to compensate for stretch with your height and light penetration restrictions. To be on the safe side, stop manipulating them 1wk before flowering IMHO. Try not to strip it all at once. Try half now, half 1wk out from flowering.
Now that I think about it, 4 weeks more vegging probably means you're scroging under those T5's, Anything under a scrog cannopy is LARF(worthless trimming nightmare). So trim what would be larf and any large inner leaves to open up the middle of what would be the cola(meristem).:harvest:
