Calling B.S. on "Must decarb or it won't work" but open to education

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BDH420

BDH420

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I kinda bypassed what everyone else has posted on this topic. But in my experience since I have been at this since 1991. We never used to decarb our trim before making medibles. It wasn't until around 2012 some time I think that we started to decarb. I do notice a big difference between the two. Especially when cooking with narrow leaf cultivars. A cultivar you would think would get you up and moving will be super couch lock after a good decarb. I just made these gummies because I'm on vacation down South and didn't want to bring a couple ounces of flower. They came out amazing super relaxing and super stoney. It takes just one. I used a half ounce of Texada Timewarp Trim and a little over a quarter cup of coconut oil. It only takes one to get you good and 2 to floor you. I did forget to spray my silicon mold and wow was it hard getting some of them out. I used this video from youtube to make them. They are very stable and don't melt when sitting out.
PXL 20220109 193418718
 
Moe.Red

Moe.Red

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Here is another peer reviewed research paper that applies:


"THCA-A lacks cannabimimetic effects; we hypothesize that it has little binding affinity at cannabinoid receptor 1 (CB1)."

Results: The THCA-A reagent contained 2% THC. THCA-A displayed small but measurable binding at both hCB1 and hCB2, equating to approximate Ki values of 3.1μM and 12.5μM, respectively. THC showed 62-fold greater affinity at hCB1 and 125-fold greater affinity at hCB2. In efficacy tests, THCA-A (10μM) slightly inhibited forskolin-stimulated cAMP at hCB1, suggestive of weak agonist activity, and no measurable efficacy at hCB2.

So in layman's terms, you have to have the cannabinoid (in this case THCA) bind to a CB1 or CB2 receptor to make it "active."

THC is 62 times better at binding to CB1 and 125 times greater at CB2.

THCA has a weak but measurable agonist activity at CB1 and none at CB2 which means it sorta maybe tickles those same receptors as THC, but that carboxyl group makes it a bad fit to properly activate the receptor.





My takeaway - even if it does get you high without decarbing, why would you leave all that proper medicine on the table and not put it to use? Is decarbing that hard?
 
MT_Smoke420

MT_Smoke420

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Here is another peer reviewed research paper that applies:


"THCA-A lacks cannabimimetic effects; we hypothesize that it has little binding affinity at cannabinoid receptor 1 (CB1)."

Results: The THCA-A reagent contained 2% THC. THCA-A displayed small but measurable binding at both hCB1 and hCB2, equating to approximate Ki values of 3.1μM and 12.5μM, respectively. THC showed 62-fold greater affinity at hCB1 and 125-fold greater affinity at hCB2. In efficacy tests, THCA-A (10μM) slightly inhibited forskolin-stimulated cAMP at hCB1, suggestive of weak agonist activity, and no measurable efficacy at hCB2.

So in layman's terms, you have to have the cannabinoid (in this case THCA) bind to a CB1 or CB2 receptor to make it "active."

THC is 62 times better at binding to CB1 and 125 times greater at CB2.

THCA has a weak but measurable agonist activity at CB1 and none at CB2 which means it sorta maybe tickles those same receptors as THC, but that carboxyl group makes it a bad fit to properly activate the receptor.





My takeaway - even if it does get you high without decarbing, why would you leave all that proper medicine on the table and not put it to use? Is decarbing that hard?
Think I'm going to potency test a batch of gummies i made with i guess my version of RSO not decarbed (besides the heat applied to it in the rice cooker / the simmer while making gummies) and a batch made after taking that oil and putting it in the oven at 250 for 30 minutes with the same amount of oil.
 
Moe.Red

Moe.Red

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Eats 100 50 mg edibles to prove point. Feels nothing. Gets angry. Still doesn't know why. Cries.
Do you have any liver or digestive conditions?

Have you ever tried a tincture dissolved under the tongue, not swallowed?


Edit - it might be genetics for you:


Some studies have found that levels of THC metabolites, the breakdown products of psychoactive tetrahydrocannabinol, vary greatly depending on the presence of a certain enzyme that breaks down THC in the liver. Which enzyme a person has depends on which variant of the CPY2C9 gene they have- with some uncommon subtypes producing an enzyme that metabolizes THC faster than normal.


The researchers thus say that presence of certain genetic subtypes that affect this liver enzyme may account for some people being unable to experience a high from cannabis edibles. They added that how easily people absorb fat may also play a role in their ability to get high from edibles.
 
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HaveApuff

HaveApuff

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I will give you this, your topic for discussion has certainly led to some very interesting readings and research on the topic by those here in the farm, and enlightening to say the least. Here are a few more articles I found that are of an interesting read.




 
smokedareefer

smokedareefer

1,773
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28 gms keif 60 min in the oven at 240 deg, stirred half way through. Made about 90 caps.

3 capsules have little if any effect for either me or my wife.

Free to anyone who wants to try them
20220124 201550
Screenshot 20220124 202838 Gallery
 
Moe.Red

Moe.Red

5,044
313
I will give you this, your topic for discussion has certainly led to some very interesting readings and research on the topic by those here in the farm, and enlightening to say the least. Here are a few more articles I found that are of an interesting read.




For those breezing thru, 3 of 4 of the linked articles say you can't get high from raw bud, the 4th does not comment, only how to do the decarb.

This is what makes me a little crazy - we have lots of evidence (much of it clinical) that raw weed won't get you high, and posters who say it does. 🤷‍♂️
 
Narsbars

Narsbars

114
28
For those breezing thru, 3 of 4 of the linked articles say you can't get high from raw bud, the 4th does not comment, only how to do the decarb.

This is what makes me a little crazy - we have lots of evidence (much of it clinical) that raw weed won't get you high, and posters who say it does. 🤷‍♂️
I know it has worked for me. It is a lot worse than spinach in your teeth. Our bodies do weird and wonderful stuff. Chew up plain crackers and if you take long enough you convert the starch to sugar in your mouth. I have no real science but since our bodies have cannabinoid receptors, maybe we have a way to convert some THCA to THC or another analogue.
 
Narsbars

Narsbars

114
28
I kinda bypassed what everyone else has posted on this topic. But in my experience since I have been at this since 1991. We never used to decarb our trim before making medibles. It wasn't until around 2012 some time I think that we started to decarb. I do notice a big difference between the two. Especially when cooking with narrow leaf cultivars. A cultivar you would think would get you up and moving will be super couch lock after a good decarb. I just made these gummies because I'm on vacation down South and didn't want to bring a couple ounces of flower. They came out amazing super relaxing and super stoney. It takes just one. I used a half ounce of Texada Timewarp Trim and a little over a quarter cup of coconut oil. It only takes one to get you good and 2 to floor you. I did forget to spray my silicon mold and wow was it hard getting some of them out. I used this video from youtube to make them. They are very stable and don't melt when sitting out.
View attachment 1210182
Are you willing to share your recipe?
 
Narsbars

Narsbars

114
28
I kinda bypassed what everyone else has posted on this topic. But in my experience since I have been at this since 1991. We never used to decarb our trim before making medibles. It wasn't until around 2012 some time I think that we started to decarb. I do notice a big difference between the two. Especially when cooking with narrow leaf cultivars. A cultivar you would think would get you up and moving will be super couch lock after a good decarb. I just made these gummies because I'm on vacation down South and didn't want to bring a couple ounces of flower. They came out amazing super relaxing and super stoney. It takes just one. I used a half ounce of Texada Timewarp Trim and a little over a quarter cup of coconut oil. It only takes one to get you good and 2 to floor you. I did forget to spray my silicon mold and wow was it hard getting some of them out. I used this video from youtube to make them. They are very stable and don't melt when sitting out.
View attachment 1210182
Are you willing to share your recipe?
Think I'm going to potency test a batch of gummies i made with i guess my version of RSO not decarbed (besides the heat applied to it in the rice cooker / the simmer while making gummies) and a batch made after taking that oil and putting it in the oven at 250 for 30 minutes with the same amount of oil.
I would think the rice cooker counts as decarbing. I dump fresh weed in coconut oil in a crock pot for a couple hours and you definitely get ripped right off the oil alone.
 
MT_Smoke420

MT_Smoke420

115
28
Are you willing to share your recipe?

I would think the rice cooker counts as decarbing. I dump fresh weed in coconut oil in a crock pot for a couple hours and you definitely get ripped right off the oil alone.
And i definitely was catching a buzz from my gummies without decarbing, unless my thermo gun was off it just didnt break the 200 threshold. This is mostly just for me to be able to make the most consistant MG gummies I can based off equipment at home. We'll see, worst case I'll be eating a bunch of gummies throughout the process haha 🍻
 
Moshmen

Moshmen

8,218
313
I am so far from your level of tolerance the idea of eating 100mg makes my balls tremble - not in a good way.

So one of the old timers here is convinced that the body does some decarbing in the digestive tract. I could never find any evidence of this and chalked it up to "forum wisdom." Do you think there is anything to that?
Absolutely not , at least not my body - inoder for me to get high from edibles or capsules it must be decarbed slow and low - then I’ll fill a gel cap with aprox 1 g of 60/65% oil . If I eat prepackaged from a dispo I need at minimum 600 mg’s 1000 if I want to sleep . I’ve been told everybody processes edibles differently? Moe your the mad scientist can you tell me why it’s so hard for me get relief from edibles - yes sunflower lechtin and nuts have helped but caps filled with oil or reclaim has been the most effective
 
Moe.Red

Moe.Red

5,044
313
Absolutely not , at least not my body - inoder for me to get high from edibles or capsules it must be decarbed slow and low - then I’ll fill a gel cap with aprox 1 g of 60/65% oil . If I eat prepackaged from a dispo I need at minimum 600 mg’s 1000 if I want to sleep . I’ve been told everybody processes edibles differently? Moe your the mad scientist can you tell me why it’s so hard for me get relief from edibles - yes sunflower lechtin and nuts have helped but caps filled with oil or reclaim has been the most effective
Check out post 45. You may have the genetic makeup that modifies a liver enzyme.
 
Moshmen

Moshmen

8,218
313
Check out post 45. You may have the genetic makeup that modifies a liver enzyme.
Good read yeah that’s possible for sure I don’t understand the whole thing but I get the jist of it - just have to make sure no one else takes my caps! Lol they tend to not wake up for a bit
 
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