So far all of my UC grows have been from seeds and the run before last I had some germination issues and ended up using seeds I had on hand to fill out the whole system. I ended up with 5 Sweet Specials, 2 Killer Kush and 1 Cream Mandarine, all from Sweet Seeds. The only one that suffered a bit was the Cream Mandarine. It's nutrient requirements were a bit less than the others. This week I harvested a full system of Blue Dream. I found it required about 75 ppm, on the 500 scale, more than anything else I've grown so far. So had I mixed it with another strain I probably would have had to compromise somewhere in the middle to accommodate both. My next grow will also be a mixed one. Six Female Seeds Ice and 2 Mephisto Chemdogging autos. Again I had some germination issues with the Ice and not having more photo seeds, threw those two autos in to fill the system. Since autos are normally run under 18 or 20 hours of light, I'm not expecting to get the most from them under 12 hours of light. Autos generally require less nutrients than photos, so that has the potential to be problematic as well. All that said, I believe you can successfully run multiple strains as long as they are close in their genetic make up, stretch and flowering time. As mentioned above, keeping an even canopy is key to getting the best results.