just a heads up, don't remove affected leaves until the problems solved. rather have them get worse than have it start on the next lowest leaves. if it's a plant issue and you remove affected leaves, the symptoms will move to new leaves and begin there. also, the cannabis plant is capable of removing leaves itself and necrotizing them for nutrition. i believe if they weren't useful to her in some way(including just not throwing away what took so much energy to create) she would shed them herself. besides only 15% of surface affected on some of those leaves, meaning they probably photosynthesize fine, especially because they're still a good green.
did you cut back on feed ppm and rinse medium? did you move that fan? i see a little nute burn and some wind damage. can you get us more photos? maybe of the white bumps you say come first? could very well be aphids/pests in the roots. what do you feed exactly right now?
Gonna mix Diatomaceous Earth
With my coco and layer some lava rocks and a fabric pot ontop of that then coco and greensand on top
Pretty sure it's root aphids fucking it up