Lighting , if power is nonissue; CMH/ or traditional Mh/ hps.
Already mentioned above, hvac, total load for removal of heat, your size, 5tons cooling / heating capacity, btu wise, 140k total.
Also consider fresh air in and exhaust out with dehumidifier.
Cooling the room will be critical with traditional lights as they do generate massive heat loads.
It’s all about the environment
Air movement consider, a fan oscillating for every 4-6 plants
Scrog net to control train the plants due to height restrictions
I’d section a veg room / mother room
And a dedicated flower space.
I do like the rolling tray / shelf idea.
Drainage, get a floor sink every 6-8 feet apart and ensure it’s a min of 4” in diameter. If the laws allow u to , you can send most run off into sewer or you may need to collect drainoff and treat locally before sewer.
Control mechanism should allow for easy access via wireless or mobile devices, if setting up I’d ensure control and security access as top priority.
Soil or media decisions will also dictate what setup will work.
But lights and hvac/ environment is same no matter which route you go.
Hydro is better to yield and control but there is a steep learning curve whereas soil is forgiving but there is issues regarding conditions control and pests.