Ca is immobie and mainly works like "bricks" the plant builds with. Once it's set in the leaf it stays there. What you're seeing now is a very slight deficiency that was present when the leaf in question was "built" This could be due to a growth spurt, a period of high humidity or cool temps and a number of other things. Any condition that slows down transpiration or outpaces what's available in the root zone at the time can cause a Ca deficiency.
Over time and exposure to the light those cells have broken down now and are finally showing their weakness. They were just missing a few bricks.
Responding to that past problem now can make the situation worse and cause a domino effect that affects your harvest.
If they were my plants I would look in my log/diary to check for any past environmental issues or changes in feeding that could be the culprit, monitor my youngest top leaves and move on. Many growers experience a slight Ca deficiency during the stretch and don't see it until it's back to normal growth rate. Then they chase their tails trying to fix a problem that's not there anymore.
Resist the urge to over mother them and pick your battles wisely.
Way more plants are killed by love than by neglect