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It looks like a lot more is going on than simply one specific enzymatic interaction with terpenes and cannabinoids. Individual terpenes and individual cannabinoids have diverse therapeutic activity with varied mechanisms of activity. There are dozens of individual compounds, many of which have...

I'll take a crack at it and throw you a few references also. Btw, I know most people don't have institutional access to scientific journals, but you can copy the URL or DOI of any paper and paste it into SciHub (a delightful Russian scientific piracy website) to get a copy of the manuscript for...

I generally agree - I personally wouldn't go out and buy a CBD or THC extract for consumption. My favorite running project is a collaboration with a research group at UC Berkeley wherein they've bred a large variety of new hemp strains by pretty traditional methods and I've helped them isolate...

I'm not a biochemist, if that's what you're asking. I'm a synthetic organic chemist, so I'm more one the path of you give me a gram of CBD isolate and I turn it into a 0.998 grams of d8THC. One of my buddies actually is a biochemist, and he uses yeast to biosynthesize cannabinoids. It's super...

I'm a PhD chemist working mostly in the clean tech industry, but I've got a little side hustle going on where I help researchers and clients working in the hemp and cannabis industries with purification, isolation, synthesis, and custom formulation. (I also help interpret sketchy COAs). I've...

You're confusing biosynthetic pathways in the plant with synthetic chemistry. You can very easily isomerize CBD to d9THC and even take it further to d8THC using pretty mundane synthetic organic chemistry. The product is exactly the same at a molecular level as a decarboxylated phytocannabinoid...

There are much cleaner syntheses with high yields of either d8 or d9 available, like 98%-100% yields of either from CBD isolate. I've overseen the d8 synthesis scaled from test-scale to 500 kg/wk cleanly and some companies I've seen are doing it with flow reactors. I'm skeptical of the yield...