Hey guys, a bit off topic, but hoping somebody could shed some light on this.

Historically, 1g of decent shrooms usually sent me on a nice trip in my younger years.

Prior to last night, the last time I tried them, it was about 5 yrs ago, and resulted in a 'no-go'. Not even a hint of a buzz. I had ultimately consumed 3.5g that evening. Anyone else that tried them seemed to get off on them.

Last night I gave it another go. I ate 2g of Dino Eggs. These are purportedly some of the most potent shrooms you can get. Started with 1g. After over an hour later, not feeling any effect. So I ate another gram. After a couple beers, a dab or two, and an hour or so later, nothing. Ultimately, I just went to bed another hour or so later, as it was getting past 1am and not feeling any effects from the mushrooms.

Now here is my question: Given I have been a chronic weed smoker for a better part of my life, could it be that cannabinoids are blocking certain receptors?

EDIT: I went to ChatGPT and asked. This is what I got.

My question:
"will cannabinoids block receptors and inhibit the psilocybin effects?"


ChatGPT answer:
Cannabinoids and psilocybin affect the brain through different systems, so the interaction between them is complex and not fully understood. Here’s a closer look at how they might interact:

1. Different Receptor Systems:
   • Psilocybin primarily acts on serotonin receptors, especially the 5-HT2A receptor, which plays a significant role in its psychedelic effects.
   • Cannabinoids interact mainly with cannabinoid receptors (CB1 and CB2) in the endocannabinoid system.
2. Potential for Modulation:
   • Cannabinoids might not directly block serotonin receptors, but they can influence the overall brain environment. This could potentially alter the subjective experience of psilocybin without completely inhibiting its effects.
   • Some studies suggest cannabinoids can modulate or change the effects of psychedelics rather than outright blocking them.
3. Lack of Clear Evidence:
   • There is limited research on the specific interaction between cannabinoids and psilocybin. Most evidence is anecdotal or from studies with other substances, so conclusions about the exact nature of their interaction are not definitive.
4. Individual Variability:
   • The effects of combining cannabinoids with psilocybin can vary based on individual differences, such as personal biochemistry and dosage.

In summary, while cannabinoids might influence the effects of psilocybin, they are unlikely to completely block them. However, their interaction is complex and not fully understood. If considering using these substances together, it’s important to proceed with caution and consult with a healthcare professional.