Coco is intersting because it can hold just as much of a root capacity as rockwool, meaning you can use much much smaller pots for a plant versus regular soil, which makes it suitable for hydro. just the same, coco retains a fair amount of moisture and has a very good CEC making it suitable as a soil base as well. So, with that being said:
Add perlite if you're treating your coco like a soil and are either adding amendments or using a huge (10 gal +) pot. Helps distribute water more evenly and really helps cut back fliers vs. straight coco in a large pot.
Use straight coco in smaller pots that are on a constant feed for hydro, feed like normal soil until they drink every day and then set up a drip. I know guys who clone into three gallon coco pots, once they drink every other day (about a month) they flower and never change the pot size, just water more frequently.