I always grow a single feminized seed, which I top and lollipop, but I'm beginning to evolve my thinking about defoliation.
I started growing with a 3'X3' tent in a 3 gallon cloth pot using a 50/50 mix of Peat and Vermiculite ammended with lime and gypsum. Five months later I've got a six ounce yield of LA Con plus 14g of kief.
Today, I grow in a 7 gallon cloth pot using CoM's Stonington Blend which was designed as the ideal soil to grow cannabis in and I'm expecting a 14 to 16 ounce yield by early March plus 2 to 3 ozs of kief.
I lollipop and top once and do alot of low stress training, but I find that I'm more of a sculptor now than a barber and my yields have not suffered in my opinion. That's my current grow at 12 days in veg and I'm keeping her short with tight nodes.