STS pro's:
Produces only female seeds
Eliminates the guesswork selecting males
Better chance of selected traits in offspring
STS con's:
Can't smoke any plants you spray
Has to be made and used fast due to short shelf life.
Big learning curve with application and timing so that seeds are viable
Possible to lock in recessive hermaphrodite traits in offspring
Regular seed pro's:
Access to greater genetic diversity in the parents (unless you're doing R1 crosses)
Much more healthy viable pollen
You can smoke your results
Regular seed con's:
You have to grow twice as many plants than you will harvest
Selecting good males can be a crapshoot in the beginning and take you backwards
Higher risk of accidental pollination of non seed crop
Needs to be outcrossed eventually to avoid inbreeding depression
Both techniques will require you to either have a second setup for breeding or to do seed only runs sometimes. With regular seeds and R1 crosses you can at least smoke the results. If you are going to use STS you should make it yourself. It has an extremely short shelf life even when stored perfectly and the shit available online is bad 75% of the time.
Good luck and keep us posted