Its crazy how similart the molecules are right?
theyre not just similar, theyre actually the same substance biologically.
That phosphorous atom sneaks it past your mao enzymes, but it still has to go to your liver to have the phosphorous atom removed.
Mushrooms are clever, psylocybin and psylocin aren't actually psychoactive, they get metabolized. theyre just DMT pro drugs, and the mushrooms have figured out how to get DMT around our gut without needing an MAO inhibitor.
The psilocybin and psilocin are steered directly through a very specific dephosphorization metabolic pathway in the liver.
as the liver dephosphorylates the psilocin and psilocybin, it releases pure DMT into your blood stream.
Psylocybin doesnt look like DMT, effectively, biologically,
IT IS dmt lol. Some psilocin will make it to receptors as psilocin, but all of the psylocybin and a portion of the psilocin, actually hit the receptors as n,n,DMT. I could be remembering wrong, but quite recently i watched something with a biochemist or something raving about this. Might have been Terence's brother Dennis lmao.
This is probably also what accounts for so many varied effects between cultivars of mushrooms lol. the different concentrations of the psilocin present, along with how much gets dephosphorylated. the whole dmt, psilocin, psilocybin package.