What I have found is that spraying one and or multiple branches . Sts get in there and affects the whole plant blocking for a shorter time frame.
You spray say and plant goes into flower mode. Male sacs appear in few weeks then another few to open. Then plant will start putting out more pistols and show and grow more female like.
Now if your isolation is to smoke those buds, I’m going to say bad idea.
Enjoy and good luck.