Cannabinoid-volatile synergism -- true or not?

beachbum87 · Sep 7, 2014

Has anyone else here done high school science? Im mostly self taught so have no real experience and not sure if I can be much help. i guess Id like to know is it true that volatiles have a synergistic effect? Im just real wary of thinking that..i mean thats just totally contrary to my understanding but Im not an expert. Isn’t this a spinoff myth from a spinoff myth than someone saying years ago some cannabinoids can offset each other so like synergistically in that sense. I just did a pubmed search and found nothing but plenty on forums.

caveman4.20 · Sep 7, 2014

Google or Google scholar Israel and cannibinoids and you can YouTube cannibinoids and see what their talking about

beachbum87 · Sep 7, 2014

Ok Ill try that thanks.

caveman4.20 · Sep 7, 2014

This might be enough....there is a ton of stuff on the farm....
Welcome to the farm!

caveman4.20 · Sep 7, 2014

beachbum87 said:
Has anyone else here done high school science? Im mostly self taught so have no real experience and not sure if I can be much help. i guess Id like to know is it true that volatiles have a synergistic effect? Im just real wary of thinking that..i mean thats just totally contrary to my understanding but Im not an expert. Isn’t this a spinoff myth from a spinoff myth than someone saying years ago some cannabinoids can offset each other so like synergistically in that sense. I just did a pubmed search and found nothing but plenty on forums.

not sure what volitile synergism is I guess I'm putting that in the search box next lol

caveman4.20 · Sep 7, 2014

caveman4.20 said:
not sure what volitile synergism is I guess I'm putting that in the search box next lol

Correct me if I'm wrong , after reading a little bit, you are asking if it is true or not true that oils evaporate that may have an impact on the total effects of the oil profile?

If that is what your asking I believe that's true and a quick search showed the synergistic factor true but I have not found the volatile part which is that if certain oils evaporate s it changes the effects....if I'm not mistaken that video i posted above talks about the change from volatility but effects are subjective to the partaker of said oil due to our individual endocannabinoid systems.....
I'm no science guy just try to understand what I can but this is all new to the world except Israel and a few other places where cannabis research is allowed

I believe certain steps in CURING process preserve said volatiles and may change them from a volatile state to an nonvolatile state

Supercharge · Sep 7, 2014

I believe he's asking if there is truth to the belief that volatiles have a synergistic effect with cannabinoids to effect potency. There is some evidence of this, here's a link to one paper on the topic.

caveman4.20 · Sep 7, 2014

Supercharge said:
I believe he's asking if there is truth to the belief that volatiles have a synergistic effect with cannabinoids to effect potency. There is some evidence of this, here's a link to one paper on the topic.

Is too late to put a poll up for this @delae632 of course if the OP so desired....

So supercharge do you think it's true aswell ?

Supercharge · Sep 7, 2014

I'm not sure I've read enough on the subject to convince me either way. It's a broad subject to try to pigeon-hole. Perhaps some volatiles do synergize with cannabinoids, but with so many in both chemical classes, there needs to be more research done to determine exactly which ones synergize with each other. On the same token, if synergisms are possible, then antagonisms are too.

caveman4.20 · Sep 7, 2014

Yup for example: some cannabis can suppress a hyperactive immune system to help it rest when the hyperactivity is unnecessary and
Some cannabis can activate hyperactive immune system when it is needed......amazing plant

As far as the synergistic effect I believe its true on many levels one very simple level is when a crack open the jar and take a whiff :nailbiting: :D and it gets me smile'n then I light it and smell the inscence:) it's working then I inhale and taste the same smells.....by the end of the joint if the taste is still their that gets me excited and usually by that time I'm plenty high but still smoke out of curiousity and the accumulitive effects of the combination of everything happening in harmony.....

As far as the antagonistic effects, personally with my own experience, i can enjoy a potent flower that doesn't appeal to my other senses and I usually conserve well with those so I'm happy but if it's not appealing any common 5 senses and it's not fullfilling my receptors demand I get a lil dissappointed but my nose stops running I might still get the munchies and even get cottonmouth....
I'm thinking synergism and antoginism may be influenced a bit by power of suggestion but not trumped by it
Did I make sense ?

Great thread!

delae632 · Sep 8, 2014

caveman4.20 said:
Is too late to put a poll up for this @delae632 of course if the OP so desired....

So supercharge do you think it's true aswell ?

If the @beachbum87 wants me to throw up a poll (which I can) then he can pm me the details.:)

caveman4.20 · Sep 8, 2014

delae632 said:
If the @beachbum87 wants me to throw up a poll (which I can) then he can pm me the details.:)

You thinks it's true Delae? On the topic

delae632 · Sep 8, 2014

caveman4.20 said:
You thinks it's true Delae? On the topic

I have no idea. I'm not really interested in this topic personally but I'd be happy to throw up a poll if the OP wants.

wobbly goblin · Sep 8, 2014

entourage effect is the term you may want to search

fwiw

caveman4.20 · Sep 8, 2014

wobbly goblin said:
entourage effect is the term you may want to search

fwiw

CNN: Medical marijuana and the 'entourage effect':

nastiestnate · Sep 8, 2014

yep it be true.

its why you have some bubble heads that turn down the majority of other concentrates not based on the butane but rather the feel of the ride.

also why you have some people say their tolerance going up from shatter imo in addition to the ease of injestion but also from the lack of compounds in concentrates thats over purged .... missing compounds being the problem.

straying from the original setup of compounds from the strain is basically in itself a different strain. these compounds make the strain and set it apart from different phenos or cuts.

without them its basically a high with no depth. bland. which is like a poorly done co2 oil or an over purged shatter.

yeah it gets you high... but its nothing remotely close to the flower it was made from. its no longer special.

but thats like marinol same problem... cannabis is more than thc,cbd,etc and more than terps and whatever other shits in it.

also these compounds and the ratios of these compounds are besides the growth factors essentially the strain. this combination is what allows the user differation in perceptions of cannabis from strain to strain or indica to sativa

beachbum87 · Sep 8, 2014

Thanks for the interest in my thread! Im not fazed about a poll. One can be put in but i dont mind either way. Im more interested in hearing discussion. Also more interested in actual physiological/chemical synergisms not so much the power of the mind type stuff. Though Im sure that factors into experience too.

Certainly seem like its not just a myth or case of chinese whispers..but still not sure i understand how this works.

Cannabinoid-volatile synergism -- true or not?

Cannabinoid-volatile synergism -- true or not?

beachbum87

caveman4.20

beachbum87

caveman4.20

caveman4.20

caveman4.20

Supercharge

caveman4.20

Supercharge

caveman4.20

delae632

IG @delae_632

caveman4.20

delae632

IG @delae_632

wobbly goblin

caveman4.20

nastiestnate

beachbum87

Cannabinoid-volatile synergism -- true or not?

Cannabinoid-volatile synergism -- true or not?

beachbum87

caveman4.20

beachbum87

caveman4.20

caveman4.20

caveman4.20

Supercharge

caveman4.20

Supercharge

caveman4.20

delae632

IG @delae_632

caveman4.20

delae632

IG @delae_632

wobbly goblin

caveman4.20

nastiestnate

beachbum87

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