Ha, yeah this is the magic question. Easy answer for me is, as often as possible! Depends a lot on your media mix, and I'm not into perlite, but for coco you want to schedule so it's always moist. The more aerated your media, the more frequent you can water. Also depends on how your system is set up, cycle-timer, drippers vs open lines, adj manifold, etc, and of course the plants' metabolism and rh in the room. Making up some test buckets to analyze helps and then you just watch closely and tweak to your desired runoff as the plants grow. Or maybe use a
blumat?
FYI, I've found grow journals to be the best place for comparing notes on this. Mimicking similar setups from members with established results is usually a good place to start, then you can adjust to your situation.