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Teaser,........ follow link for entire paper:
Impact of Genome Decoding
Before the sequencing of the cannabis genome, about 12 cannabis genes were known, and now tens of thousands are known, said McKernan. Additionally, the genome has provided a better understanding of THC synthase genomics, as well as more than 2 million single nucleotide variants.
McKernan also noted that the genome has made apparent that THC synthase is not one gene with 2 copies in a diploid genome, “as all of the previous papers have postulated.” Instead, the recent sequencing implies that the gene has been replicated 8 times—with the potential assistance of a transposable element—and diverged.
In discussing the genome's importance with NPR, McKernan said it will allow scientists to investigate the genes that govern cannabis compounds other than THC and CBD, and to sequence other cannabis strains to highlight different traits.1 Leading cannabinoid researcher Ethan Russo, MD, finds these possibilities “very exciting.”
“The publication of the cannabis genome is a welcome scientific development," said Dr. Russo, “but one whose potential applications remain to be determined. The possibilities are enticing, and it seems certain that many able minds will apply their imagination to the task. Every phytocannabinoid that has been closely researched so far has demonstrated unique therapeutic potential. There are hundreds of strains available on the black market, but these are not necessarily stable and reproducible”
Impact of Genome Decoding
Before the sequencing of the cannabis genome, about 12 cannabis genes were known, and now tens of thousands are known, said McKernan. Additionally, the genome has provided a better understanding of THC synthase genomics, as well as more than 2 million single nucleotide variants.
McKernan also noted that the genome has made apparent that THC synthase is not one gene with 2 copies in a diploid genome, “as all of the previous papers have postulated.” Instead, the recent sequencing implies that the gene has been replicated 8 times—with the potential assistance of a transposable element—and diverged.
In discussing the genome's importance with NPR, McKernan said it will allow scientists to investigate the genes that govern cannabis compounds other than THC and CBD, and to sequence other cannabis strains to highlight different traits.1 Leading cannabinoid researcher Ethan Russo, MD, finds these possibilities “very exciting.”
“The publication of the cannabis genome is a welcome scientific development," said Dr. Russo, “but one whose potential applications remain to be determined. The possibilities are enticing, and it seems certain that many able minds will apply their imagination to the task. Every phytocannabinoid that has been closely researched so far has demonstrated unique therapeutic potential. There are hundreds of strains available on the black market, but these are not necessarily stable and reproducible”
