So something to keep in mind here is that cells are always looking for equilibrium, in this case we are looking at the water and compounds within the individual cells. If the root cells are constantly surrounded by only H2O the cells will release salts from within the cells to create that equilibrium around the root cells. This process does not occur quickly so in the case of top feedings that go drain to waste this will virtually never be an issue. In the case of DWC it may become more of a problem.
So just for full disclosure I have never been afraid to apply plain distilled or RO water to plants, but then again I have been predominantly a soil grower so my roots have always had buffer around them. I am not trying to make people afraid of using pure H2O, it is a great tool and I love it. Just laying out things as I have learned them.