When you top or prune or defoliate, you lose the recovery days that would have been growth days. Especially in early flower when veg growth is strongest. Maybe one heavy defoliate or prune. Topping would take too much time to see new growth to become much. By week 3-4 all veg growth stops and focus is budding. So you have a tiny window for stress. Less stress is best, but if you are going to do it, hit it hard and let her glide stress free. Especially week 3-6 let her focus on working and not correcting. So I’d say probably not a good idea.