The main reason I don't run perpetual is because I believe in clean cannabis. I don't use anything in the flower room except nutes for the plants. No sprays, pesticides, organicides, fungicides... nothing. E20, you mean
Eagle 20? I won't touch the stuff, even in veg. I use safer's 3-in-1 and iso/water for pest control in veg, I throw away mums which are infected with pm or other fungal issues. Start clean, finish clean.
Bleach and h202 should be plenty harsh enough to remove any traces of most nasties. I've found hepa filters on the intakes to be extremely helpful. Helpful for more than just scrubbing spores out of the air, also for keeping dust and other common contaminates off your flowers. (That burnt ashtray smell, from most cannabis, is not from cannabis, it's from contaminates in-on cannabis.)
As long as you're flowering plants at different stages, in the same room, expect problems to arise where the only correct decision is to wipe everything and start over.