Here's an interesting read on this subject: It involves enzymatic formation of acidic by-products, and pH buffers.
They can be added to the reaction mixture in 2 different forms: organic soluble and solid-state (insoluble). The aim of this chapter is to present the practical methods for utilisation of these novel buffers with biocatalysts in organic media.
This is some cutting edge shit....
Solid state buffers
These buffer pairs exist as crystalline solids which exchange H+ with Na+ (in control of aH+/aNa+) or accept/donate H+ and Cl- together (in control of aH+.aCl-) in order to control the protonation state of the enzyme. In general, a zwitterion along with the appropriate salt is used since the pair must be insoluble in the organic reaction mixture. Unlike the organic soluble buffers, each buffer pair will set a fixed value of the relevent ionisation parameter, regardless of the quantities of each form used. Also, they can be used in a number of solvents since their ionisation is independent of the nature of the solvent.
The usefulness of a range of solid state buffers for control of pH+pCl (e.g. Lys/Lys.HCl) has been shown for immobilised subtilisin in hexane and toluene (2). Similarly, pH-pNa solid state buffer pairs have recently proved successful for reactions in both polar and non-polar solvents with different forms of the same enzyme
I'm suggesting that azomite might represent a "shotgun" approach to doing just that...
If techniques like this could be "custom tailored" for cannabis, the results could be phenomenal