Milson
Milsonian
Supporter
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- 263
I like this effect too. Idk if this part is THCV or what but I associate it with clean sativas. Maui Wowie has been my fav strain for this so far but I agree a good sour diesel does it too.
Moe.Red
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- 313
I don't know either, that is why I am pulling the plant apart and putting it back together with specific components. Could be THCV, terpenoids, entourage, who knows. But I know it when I feel it.
It would actually be easier if it was not THCV and we could duplicate it with what we already have, but my vote is that THCV plays a dominant role in making this happen.
TripsRabbit
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- 163
I have also had sour diesel that made me wanna take a nap so it's a specific pheno or even specific plant.
Moe.Red
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- 313
Hehe, UVA works. (Far Red too)
Moe.Red
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Early prototype. It now serves as Octopi for my 3D printers.
Current software proto
Hardware proto.
Electronics station
@tobh , lemme know if you want to write some PI software.
Moe.Red
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- 313
I think it is cool how many new people are participating in this. At some point soon, we will likely be doing a crowdsourced chemotype hunt. If you want to test some genetics for us in a few months, please let me know.
It also occurs to me some parts of my lab have not been formally introduced. Allow me to rectify that right now.
It also occurs to me some parts of my lab have not been formally introduced. Allow me to rectify that right now.
Moe.Red
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- 313
Tetrahydrocannabivarin (THCV) is a propyl analogue of THC. THCV is usually low in concentration in dried plant material. However, weights up to as high as 16% THCV by dry weight have been recorded.
(Meijer & Hammond, 2005).
THCV can behave as both an agonist and an antagonist at CB1 receptors depending on the concentration
(Pertwee, 2008).
THCV produces weight loss. In tests in obese mice (Ratatouille gone wrong), THCV decreased body fat and serum leptin concentrations, with increased energy expenditure.
(Riedel et al.2009).
THCV has demonstrated prominent anticonvulsant properties in rodent cerebellum and pyriform cortex
(Hill et al., 2013).
Tetrahydrocannabivarin (THCV) on Parkinson's Disease:
Acute administration of THCV attenuated the motor inhibition caused by 6-hydroxydopamine mice.
(Garcia et al 2011)
THCV has therapeutic potential for ameliorating some of the negative, cognitive and positive symptoms of schizophrenia.
(Cascio et al 2015)
Special thanks to Dr. Ethan Russo and Jahan Marcu PhD for their publishing: Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Which collated much of the information here.
(Meijer & Hammond, 2005).
THCV can behave as both an agonist and an antagonist at CB1 receptors depending on the concentration
(Pertwee, 2008).
THCV produces weight loss. In tests in obese mice (Ratatouille gone wrong), THCV decreased body fat and serum leptin concentrations, with increased energy expenditure.
(Riedel et al.2009).
THCV has demonstrated prominent anticonvulsant properties in rodent cerebellum and pyriform cortex
(Hill et al., 2013).
Tetrahydrocannabivarin (THCV) on Parkinson's Disease:
Acute administration of THCV attenuated the motor inhibition caused by 6-hydroxydopamine mice.
(Garcia et al 2011)
THCV has therapeutic potential for ameliorating some of the negative, cognitive and positive symptoms of schizophrenia.
(Cascio et al 2015)
Special thanks to Dr. Ethan Russo and Jahan Marcu PhD for their publishing: Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Which collated much of the information here.
Milson
Milsonian
Supporter
- 3,376
- 263
Thanks! Looking up that Garcia paper eventually led me to a paper on the brain imaging of a Parkinson's patient with Pisa syndrome out very recently.
The area of the brain they found abnormality in is the same area THCV affects (basal ganglia). That same area is where the damaged cells are up-regulating CB2 receptors.
An interesting data point to toss into my web of associations....
MIMedGrower
- 17,190
- 438
Just a thought. And i have background in the natural medicine industry and come from a family with science and medical phd’s.
What i notice is they always want to isolate a cannabinoid and find cause of action of course. Then make a specific med with just or mostly that studied cannabinoid. Like cbd drops.
unfortunately for most patients the isolated cannabinoid no longer has the effect it did when still in the full “recipe” of everything in the weed.
This is why we “spam” more than one element in natural medicine.
And yes i know i have said this before. But turning weed into pharmacology isnt how this will work in my opinion. Its how we get opiates instead of medicine.
Once you isolate the patient tends to recieve no benefit. MD’s look only at the specific cause of action. Naturopaths look at the body and mind as a whole.
Just some thoughts.
What i notice is they always want to isolate a cannabinoid and find cause of action of course. Then make a specific med with just or mostly that studied cannabinoid. Like cbd drops.
unfortunately for most patients the isolated cannabinoid no longer has the effect it did when still in the full “recipe” of everything in the weed.
This is why we “spam” more than one element in natural medicine.
And yes i know i have said this before. But turning weed into pharmacology isnt how this will work in my opinion. Its how we get opiates instead of medicine.
Once you isolate the patient tends to recieve no benefit. MD’s look only at the specific cause of action. Naturopaths look at the body and mind as a whole.
Just some thoughts.
Milson
Milsonian
Supporter
- 3,376
- 263
I have been thinking of this as pursuing densities or mechanisms and i am firmly in the former w.r.t. interactions between the plant and the brain because nobody understands either very well (i have followed my father seeing neurologists at the University of michigan, mayo clinic, and northwestern. All smart people, but they are flying pretty blind relative to, for instance, a structural engineer....we just haven't made as much progress on what is an insanely complex and technology-pushing field).
W.r.t. growing, i think there are many mechanisms that are actually readily apparent and teasing those apart is cool...
And in this instance, the question "what are the effects between the brain of someone i care about and this cannabinoid that has an entirely different precursor" goes, i think, into an area where you are not attempting to unweave a density (as we are in, say, focusing on a terpene to see if we can pull apart just one or a few pieces of an entourage effect) but rather changing areas to poke. This is, imo, a more substantial difference than scientifically-silly distinctions like indica/sativa and a worthy pursuit.
How hard I dive into that pursuit is TBD but at least I want to grow out one strain that i think should have it (Ethiopian from Ace) in part because I am curious about its potential as a component of daytime medicine even outside any potential effects for my father (which would be a dream but I'm not holding my breath).
Moe.Red
- 5,044
- 313
Starting a new tradition, Friday Nite TLC. Here's edition 1. I'm chunking thru the video now.
The 2 on the left are the 2 Jack the Rippers from the last harvest. The ones that got abused.
Next is Northern Lites
Right is Blue Cheese
I took a JtR bud to the lab on Thursday to do a check on my testing vs. what a commercial lab finds. Posting this first means I can't change my result to fit the data for the doubters out there.
The 2 on the left are the 2 Jack the Rippers from the last harvest. The ones that got abused.
Next is Northern Lites
Right is Blue Cheese
I took a JtR bud to the lab on Thursday to do a check on my testing vs. what a commercial lab finds. Posting this first means I can't change my result to fit the data for the doubters out there.
TripsRabbit
- 1,259
- 163
How do you tell how much THCv is in it from that?
TripsRabbit
- 1,259
- 163
You can run a duct to an inline fan when it's really cold outside and draw in outside air to cool your lung room or tent. Just plug the fan into a temp controller. Redneck AC.
Moe.Red
- 5,044
- 313
I'm uploading 2 vids. I'll post the explanation in just a few minutes.
Moe.Red
- 5,044
- 313
I resemble that remark
Moe.Red
- 5,044
- 313
Yes, you have said this a number of times before, and I just shake my head every time I read it. I wonder if you are so dug in on your opinion that new evidence would not pierce your armor?
BTW - You get nobody is doing what you are referring to here, right? I got spam on the menu here too. Were working on growing a THCV rich strain. How is that any different from any of the potential seed choices out there as it pertains to your post? Lots of people grow for specific traits, no really everybody does.
Moe.Red
- 5,044
- 313
@TripsRabbit , here is the explanation
Moe.Red
- 5,044
- 313
I really hope this can help your dad. I'm optimistic. Weed is far from a miracle cure some make it out to be, but I think it has it's moments. This could be one.
Aqua Man
- 26,480
- 638
I think all that stuff is gonna take years... they need to isolate, test and understand each then try to figure out relationships and interactions which compounds as you add more and more cannabinoids to it.... makes my head spin thinking about it.
Moe.Red
- 5,044
- 313
I'm trying to do that with just one person. Try something - instant feedback. Try something else, instant feedback. My wife doesn't work so we can get a lot of testing done pretty quickly.
Last night she had a killer headache. Vaped some 8mo weed tested high in CBN and .02mL of 70% myrcene and she slept sound for 9 hours. Sometimes the best thing you can do for head pain is just be unconscious. She just needed help over the hump.
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