Hey there, I'm new to this site, hopefully I can give some insight to your question, I won't pretend to have all the answers, as I have many of my own. So this is what I've learned about mainlining, that's what I do due to limited space, I've found it to be really easy and beneficial. It helps with over crowding, all the work is front loaded, and results are great. One of the important things I've learned is selection of strains. ie: indica, sativa or hybred. Try to match your flower time in weeks as close as possible much easier. I have done a few grows with mixed strains, you have to be vigilant when doing this as your on different time frames. I generally flip when they reach half my desired height, that works best for indica and some hybreds. Sativa grow taller so adjust accordingly. This method keeps my grow space well ventilated and not so crowded. The yields are much better if done right. Much easier for taking care of the girls too. I hope this is of some help, I don't know everything about growing, that's another reason I do it constantly learning and improving. Happy growing, and if I've left anything out please feel free to inform me. Peace out!