With regard to tolerance, our experiments with end of life patients trying to build their tolerance to a gram a day dosage rate, for the Rick Simpson cure, suggested that tolerance ranged from the few ultra low tolerance patients whom were discombobulated at .25X dose, to about average low tolerance dosage of 1X without discombobulation, upwards to ultra high tolerance at about 3X dose. We always started unknown tolerance patients out at .25X dose.
1X dose of our HS Oil, or sublingual troches, was 100 mg. Excluding the ultra sensitive minority, as standard tolerance 1X dose patient, would be discombobulated at 2X, but a 3X patient might be functionally stupid, but still functioning at 6X, depending on how long they have been high tolerance.
It also depends on the mix, as both CBD and CBN mollify the effects of the THC, as does the entourage of mono and sesquiterpenes that are in cannabis essential oils. We were able to use higher dosages and increase the dosage faster, using a strain like Cannatonic, with close to a 50%/50% split on THC and CBD at around 14% each.
At Dr Melamede's advice, we also started providing patients with Citicolene at 3X the oil dosage, 20 minutes before taking the oil sublingual. It also assuages the effects of the THC, allowing the patient to build higher dosages faster, without discombobulation.
When I became an Oregon OMMP patient around a decade ago, I was still recovering from trauma related to youthful debauchery, and developed high tolerance rapidly, so that my pain dose was 300 Mg twice a day. Time and two biomechanical knees, have reduced my dosage to a 200 mg sublingual troche once a day, and I dab using an electric Ti nail for any head effects I desire.
Not getting high, doesn't mean zero head effects. I can watch things going on in my head, just like I watch my body relax, and note when the activity level is increased and my short term memory become erratic. If I stay on it, my short term memory becomes so erratic, that at any sidetrack in the conversation, I may lose track of what we are talking about, and have to be reminded but someone else in the group.
If we have all been dabbing equally, often no one else in the group can remember either by that point, so it appears to be a common affliction at heavy dosage levels.
What is missing in the "high" is the elated feelings. It is replaced with more of a relaxed sense of well being an nominal dosages levels.
The other thing I note at high dosages, is that I am more lethargic than relaxed and don't handle extreme stress as well. I find it harder to find the right words to express myself, and I feel higher levels of frustration, as well as being more excitable.
As a last thought, part of the lethargy are entourage monoterpenes like b-
Myrcene, which will couch lock you all by itself, so never lose track of the huge effect the strain itself has.
