Transdermal Patch

My fiancé has a brain tumor and has experimented with over 40 of these patches.

I also have tried the cbd and indica for chronic pain and insomnia.

I don't know how to makes them but I can answer questions related to the subject and tell you where to find compassionate people who don't charge $16.

Bob
 
I just want reply to a few things said here.

IMHO
Mary's Medicinals makes a very consistent and safe product. I'm impressed with this, far beyond some companies making extracts, especially cannabinoid specific. After a horrible experience with a local company making RSO (tears) out of the trim off the floor, I think this is better.

In my own experience I have taken many medications including cannabis via transdermal. I have a opioid patch on right now. I dab for breakthrough pain. It works better than a patch, but that's not what patches are for. They are for long term use, to build a level of a certain drug in your system. It takes awhile for some drugs, shorter for others. The patch I have on limits my cluster headaches to maybe a couple a week, but doesn't touch the ripped tendons and lack of cartilage in my knees.

PM me for compassionate pricing.
I would love
 
Lol if OP is still around. Perhaps suppository would be cheap and easy way to get similar effects. Ie bypass first pass liver metabolism. Measured tincture or hash in some cocoa butter and ur off to the races.
 
View attachment 441774 can anyone tell me how to make Mary's Medicinal Transdermal Patches?
[00108] Preparation of transdermal patch. The cannabis essential oil containing cannabinoids was extracted from cannabis by solvent extraction (via heptane, supercritical C02, ethanol, butane, isopropyl alcohol or combinations thereof). The oil was purified under vacuum pressure and heat. After testing for cannabinoid levels, the oil was mixed with equal parts of skin permeation enhancers and carrier agents and a long chain silicone polymer in a ratio calculated to ensure accurate dosing. 10 g of THC (as tested) in cannabis essential oil was combined with the carrier composition. The carrier composition was made with 5 g of oleic acid, 4.5 g of eucalyptol, 0.5 g of dodecyl methyl sulfoxide. The resulting composition was then mixed with 114.3 g of the polymer (long chain silicone polymer). The polymer blend was sheeted at approximately 0.152 mil. The sheets were cured at room temperature for a minimum of 8 hours. After drying, a foam backing layer is applied prior to cutting into product's final 2*2 inch size, with 10 mg THC per dose.
[00109] Use. The protective coating layer was removed. The adhesive side of the transdermal patch was applied to the skin in a no fatty veinous area of the body such as the inner wrist or top of foot. The therapeutic effects of pain relief were felt within 10 minutes and had duration of up to 12 hours. The area was washed with soap and water after wear. The application site was cleaned with isopropyl alcohol before application.

--The only part of the ingredients they are leaving out is the addition of Chamomile oils. My break down of their ingredients matches their patent otherwise.--​

  • Long Chain Silicone Polymer Blend [SSA substituted PDMS*],
  • Cannabinoid Extract [winterized],
  • (9Z)-Octadec-9-enoic acid [Oleic Acid],
  • Eucalyptol,
  • Dodecylsulfinylmethane [DMSO],
  • Water,
  • a-pinene, camphene, b-pinene, sabinene, myrcene, 1,8-cineole, y-terpinene, caryophyllene, and propyl angelate and butyl angelate [all from Roman chamomile oil],
  • chamazulene, a-bisabolol, bisabolol oxide A, bisabolol oxide B and bisabolone oxide A [all from German chamomile oil].

*elastomeric silicone soft skin adhesive (SSA) substituted polydimethylsiloxane (PDMS). The adhesive is SSA which is based on cross-linked silicone elastomer technology. SSAs are cross-linked polydimethylsiloxanes with low amounts of free extractable molecules.

The chemical agents are being suspended in a special adhesive with inherent time release properties; which means that any attempt to apply the chemical agents to something like a generic gauze bandage will result in a much quicker release of the agents and could result in nasty side effects similar to those felt when a person inhales too much cannabis at one time. Also, any contaminants that might be present in the chemical agent mixture can be transferred to your blood stream and cause major health risks so be cautious.

#### DO NOT TRY TO PARTICIPATE IN ANY FORM OF FINANCIAL TRADE WITH A DIY TRANSDERMAL PATCH USING THE ABOVE RECIPE UNLESS YOU HAVE LEGAL PERMISSION FROM MARY'S MEDICINALS LLC. ###
Although, I believe you can make them and use them for your own ailments!!!
**I am a biochemist, and NOT a lawyer, so I am only stating opinions and NOT legal advise.**
 
[00108] Preparation of transdermal patch. The cannabis essential oil containing cannabinoids was extracted from cannabis by solvent extraction (via heptane, supercritical C02, ethanol, butane, isopropyl alcohol or combinations thereof). The oil was purified under vacuum pressure and heat. After testing for cannabinoid levels, the oil was mixed with equal parts of skin permeation enhancers and carrier agents and a long chain silicone polymer in a ratio calculated to ensure accurate dosing. 10 g of THC (as tested) in cannabis essential oil was combined with the carrier composition. The carrier composition was made with 5 g of oleic acid, 4.5 g of eucalyptol, 0.5 g of dodecyl methyl sulfoxide. The resulting composition was then mixed with 114.3 g of the polymer (long chain silicone polymer). The polymer blend was sheeted at approximately 0.152 mil. The sheets were cured at room temperature for a minimum of 8 hours. After drying, a foam backing layer is applied prior to cutting into product's final 2*2 inch size, with 10 mg THC per dose.
[00109] Use. The protective coating layer was removed. The adhesive side of the transdermal patch was applied to the skin in a no fatty veinous area of the body such as the inner wrist or top of foot. The therapeutic effects of pain relief were felt within 10 minutes and had duration of up to 12 hours. The area was washed with soap and water after wear. The application site was cleaned with isopropyl alcohol before application.

--The only part of the ingredients they are leaving out is the addition of Chamomile oils. My break down of their ingredients matches their patent otherwise.--​

  • Long Chain Silicone Polymer Blend [SSA substituted PDMS*],
  • Cannabinoid Extract [winterized],
  • (9Z)-Octadec-9-enoic acid [Oleic Acid],
  • Eucalyptol,
  • Dodecylsulfinylmethane [DMSO],
  • Water,
  • a-pinene, camphene, b-pinene, sabinene, myrcene, 1,8-cineole, y-terpinene, caryophyllene, and propyl angelate and butyl angelate [all from Roman chamomile oil],
  • chamazulene, a-bisabolol, bisabolol oxide A, bisabolol oxide B and bisabolone oxide A [all from German chamomile oil].

*elastomeric silicone soft skin adhesive (SSA) substituted polydimethylsiloxane (PDMS). The adhesive is SSA which is based on cross-linked silicone elastomer technology. SSAs are cross-linked polydimethylsiloxanes with low amounts of free extractable molecules.

The chemical agents are being suspended in a special adhesive with inherent time release properties; which means that any attempt to apply the chemical agents to something like a generic gauze bandage will result in a much quicker release of the agents and could result in nasty side effects similar to those felt when a person inhales too much cannabis at one time. Also, any contaminants that might be present in the chemical agent mixture can be transferred to your blood stream and cause major health risks so be cautious.

#### DO NOT TRY TO PARTICIPATE IN ANY FORM OF FINANCIAL TRADE WITH A DIY TRANSDERMAL PATCH USING THE ABOVE RECIPE UNLESS YOU HAVE LEGAL PERMISSION FROM MARY'S MEDICINALS LLC. ###
Although, I believe you can make them and use them for your own ailments!!!
**I am a biochemist, and NOT a lawyer, so I am only stating opinions and NOT legal advise.**
Long Chain Silicone Polymer Blend [SSA substituted PDMS*], -----is the band aid
(9Z)-Octadec-9-enoic acid [Oleic Acid ---is omega 9 or in laymens term---safflower oil

fwiw
 
Long Chain Silicone Polymer Blend [SSA substituted PDMS*], -----is the band aid
(9Z)-Octadec-9-enoic acid [Oleic Acid ---is omega 9 or in laymens term---safflower oil

fwiw
Thanks Wobbly!

Constituents of safflower oil "(6% palmitic, 12% oleic, 74% linoleic acids)" according to NCBI. The fact that it's derived from safflower oil definitely makes me feel better about using oleic acid!

_____________________________________
On a side note, further research has shown that Mary's started their formulations using PLO gel, but actually switched to the above listed formulation. I believe they did this because of the reduced effectiveness of PLO gel for use with high viscosity hydrophobics, like cannibinoids, as other researchers have detailed here.


Lecithin & oleic acid are primary component of many PLO formulations, and was initially used as is shown, supported by their patent application at the time. You'll notice that they didn't fully list all the constituent parts of their formula in the first version and they choice, or were forced, to remedy this issue in future labeling. In their second formulation they switched to a DSMO type formulation with more accurate labeling, supported by their second patent application.
 
thx for the input pm

just a footnote on the safflower oil
it comes two ways depending on how it's processed
high in monounsaturated fat and the other type is high in polyunsaturated fat
the high mono is oleic aka omega 6
the high poly is linoleic aka omega 9
the high poly is harder to find and more expensive but it is available on amazon

fwiw
 
"dodecyl methyl sulfoxide" dmso lik i said.
this is used in many applications as a "carrier agent" basically a solvent that carries a drug payload thru the skin into the blood
im sure the other ingrients help to but i bet this dose the heavy lifting
 
Top