What you say is all true. (don't know about the man boobs part though)
I'm not disputing any of that. But given proper starting materials great things are truly possible with a little patience; sound technique and following solid protocols.
Genetic drift is a real thing; but it's happening always, even in the original plant. Time can't be held hostage; change is inevitable. ect... I'm also not suggesting it can be done indefinably either; gen>gen>gen>ect... at some point male genetics needs to be re-infused from somewhere.
However true isolate cut's aren't male; thus the delemma.
I agree there's lot of confusion about breeding in general; and what s1 or f3>f4 actually means. A cut vs cross; ect.
A single generation isn't terribly significant IMO;
especially if both are elite cuts taken from a flawless; properly cared for mother.... If it's done though breeding two females; or a cut from an original; drift is drift. At least in theory. Locating the "proper flawless cut" becomes the critical "link"
Personally, I think there's lot of people breeding "seeds" blindly; without vetting the phenotypes. That's the #1 rookie error IMO; or at minimum in the top three. Or breeding an unknown male, onto a vetted female, and hoping
it good. That can pump out some great seeds still; (then isolate and mother it) but the overall consistency is going to be far lower IMO. You might end up with a "special" different;
but it's still different. Then you need to spend even more time getting it to an f3>f4 state... (of Mrs Different) Lots of time and what... exactly... What if your already starting with (2) identical synthetic (monozygotic) f4's???
Females > females are far, far more predictable. But that's just my opinion; everyone is entitled to one.