Hermitian
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There's like a group of you people that seem to just sit around waiting to make another doomsday vilification thread about some product, and ya'll are annoying as fuck with your preaching. Can it.
There's like a group of you people that seem to just sit around waiting to make another doomsday vilification thread about some product, and ya'll are annoying as fuck with your preaching. Can it.
seriously?
you can totally choose not to read it
just go ahead and stick your head in the sand
ok look, same time this thread came up I saw half a dozen others between here and another site including people spouting insanity like "one drop on your skin and you will get cancer".
So this was the thread I dumped in. So sorry. Been a shitty time lately I'm getting straight robbed by a university through the govt. and in a bad mood.
Seamaiden, I reread your original post and this isn't exactly the thread I took it for. You are, of course, dead on that we should rotate products with different modes of action and use these products carefully. If a person doesn't know that they shouldn't be farming, but I suppose they do have to learn it somewhere initially, and why not here.
I'll maintain my opinion on the safety of myclobutanil, however.
rats were fed diets containing myclobutanil (79.6% purity) at concentrations of 0, 10, 30, 100, 300, 1000, 3000, 10000 and 30000 ppm for 3 months. The No Observed Effect Level (NOEL) was 100 ppm for males (equal to 4.9 mg ai/kg bw/day)
...
mice were fed diets containing myclobutanil (79.6% purity) at concentrations of 0, 3, 10, 30, 100, 300, 1000, 3000 and 10000 ppm for 3 months. The NOEL was 300 ppm for both males and females (equal to 44 mg ai/kg bw/day)
...
In a range-finding study, two beagle dogs/sex/dose were fed diets containing myclobutanil (78.4% purity) at concentrations of 0, 50, 250, 1000 or 4000 ppm for 4 weeks. The study NOEL was 250 ppm (equal to 7 mg ai/kg bw/day)
Sprague-Dawley rats were fed diets containing myclobutanil (90.4% and 91.4% purity) at concentrations of 0, 50, 200 and 800 ppm for 24 months. There was no evidence of oncogenicity. The study NOEL was 50 ppm (equal to 2.5 mg ai/kg bw/day for male rats and 3.2 mg ai/kg bw/day for female rats).
...
mice were fed diets containing myclobutanil (90.4% purity) at concentrations of 0, 20, 100, and 500 ppm. There was no evidence of oncogenesis. The study NOEL was 20 ppm (equal to 2.7 mg ai/kg bw/day for male mice and 3.2 mg ai/kg bw/day for female mice)
In a two generation two-litter per generation reproduction study, myclobutanil (78.4% purity) was administered in the diet to Sprague-Dawley rats at concentrations of 0, 50, 200 and 1000 ppm. P1 rats were treated for 8 weeks before mating, during mating, gestation, and lactation. F1a (P2) rats were exposed through their lives including at least 8 weeks after weaning at 22 days and before mating. The NOEL for parental effects was 50 ppm (equal to 3.7 mg ai/kg bw/day). General toxic effects were recorded at 200 ppm (15 mg ai/kg bw/day)
An ADI of 0.025 mg/kg bw/day has been assessed based on a NOEL of 2.5 mg/kg bw/day in a 2-year rat study and use of a 100-fold safety factor.
on apples and grapes respectively, and a preharvest interval (PHI) of 14 days
This stuff says right on the label to not let runoff go into rivers or lakes because it will fuck them up
Do not apply directly to water or to areas where surface water is present, or to intertidal areas below the mean high water mark. Do not contaminate water when disposing of equipment washwaters. Do not apply when weather conditions favor drift or runoff from areas treated.
Extensive residue data generated using the above methods have shown that when crops are treated in accordance with the label directions (multiple applications at 136 g ai/ha for apples and 80 g ai/ha for grapes and the last application at 14 days before normal harvest), the following maximum residue limits (MRL) may be required to cover the total residues of the parent myclobutanil and its major metabolites:
Apples 0.5 ppm
Grapes 1.0 ppm
Raisins 10.0 ppm
The theoretical daily intake (TDI) of residues by the general population for the proposed uses on apples and grapes, including processed products of apples and grapes, the intake from wine consumed by the total adult population, and potential residues in meat and milk, assuming maximum residues at all times, would not exceed 0.0030 mg/kg bw/day, and represents approximately 12% of the ADI of 0.025 mg/kg bw/day.
maybe u need to rotate the milk / baking soda but no need to rotate one spray of eagle job done no resistance at all
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