rats were fed diets containing myclobutanil (79.6% purity) at concentrations of 0, 10, 30, 100, 300, 1000, 3000, 10000 and 30000 ppm for 3 months. The No Observed Effect Level (NOEL) was 100 ppm for males (equal to 4.9 mg ai/kg bw/day)
...
mice were fed diets containing myclobutanil (79.6% purity) at concentrations of 0, 3, 10, 30, 100, 300, 1000, 3000 and 10000 ppm for 3 months. The NOEL was 300 ppm for both males and females (equal to 44 mg ai/kg bw/day)
...
In a range-finding study, two beagle dogs/sex/dose were fed diets containing myclobutanil (78.4% purity) at concentrations of 0, 50, 250, 1000 or 4000 ppm for 4 weeks. The study NOEL was 250 ppm (equal to 7 mg ai/kg bw/day)
mg ai/kg bw/day is milligrams of active ingredient per kg of body weight per day.
What do you weigh? Let's say 80 kg. How much Eagle do you have to drink before you reach 400 mg of myclobutanil? I'm thinking about 2 Liters. And that would still be considered NOEL.
Sprague-Dawley rats were fed diets containing myclobutanil (90.4% and 91.4% purity) at concentrations of 0, 50, 200 and 800 ppm for 24 months. There was no evidence of oncogenicity. The study NOEL was 50 ppm (equal to 2.5 mg ai/kg bw/day for male rats and 3.2 mg ai/kg bw/day for female rats).
...
mice were fed diets containing myclobutanil (90.4% purity) at concentrations of 0, 20, 100, and 500 ppm. There was no evidence of oncogenesis. The study NOEL was 20 ppm (equal to 2.7 mg ai/kg bw/day for male mice and 3.2 mg ai/kg bw/day for female mice)
Still can be exposed to an awful lot for extended periods of time. This would be about a Liter per day for 2 years for you and me.
In a two generation two-litter per generation reproduction study, myclobutanil (78.4% purity) was administered in the diet to Sprague-Dawley rats at concentrations of 0, 50, 200 and 1000 ppm. P1 rats were treated for 8 weeks before mating, during mating, gestation, and lactation. F1a (P2) rats were exposed through their lives including at least 8 weeks after weaning at 22 days and before mating. The NOEL for parental effects was 50 ppm (equal to 3.7 mg ai/kg bw/day). General toxic effects were recorded at 200 ppm (15 mg ai/kg bw/day)
It's not even harmful to pregnant animals in substantial doses.
An ADI of 0.025 mg/kg bw/day has been assessed based on a NOEL of 2.5 mg/kg bw/day in a 2-year rat study and use of a 100-fold safety factor.
0.025 mg/kg bw is still probably 10 ml of Eagle. That's a government sanctioned allowable food intake, with 100-fold safety factor.
After my next application of
Eagle 20 I will have used less than 10 ml total, ever, on plants that never saw a bowl.
on apples and grapes respectively, and a preharvest interval (PHI) of 14 days
You want to exchange quotes?
This stuff says right on the label to not let runoff go into rivers or lakes because it will fuck them up
Really? That's what the label says? You need to improve your critical thinking skills and reading comprehension.
Do not apply directly to water or to areas where surface water is present, or to intertidal areas below the mean high water mark. Do not contaminate water when disposing of equipment washwaters. Do not apply when weather conditions favor drift or runoff from areas treated.
That's what the label says. And it applies to agricultural use, where you measure in gallons of active ingredient per hectare.
Extensive residue data generated using the above methods have shown that when crops are treated in accordance with the label directions (multiple applications at 136 g ai/ha for apples and 80 g ai/ha for grapes and the last application at 14 days before normal harvest), the following maximum residue limits (MRL) may be required to cover the total residues of the parent myclobutanil and its major metabolites:
Apples 0.5 ppm
Grapes 1.0 ppm
Raisins 10.0 ppm
The theoretical daily intake (TDI) of residues by the general population for the proposed uses on apples and grapes, including processed products of apples and grapes, the intake from wine consumed by the total adult population, and potential residues in meat and milk, assuming maximum residues at all times, would not exceed 0.0030 mg/kg bw/day, and represents approximately 12% of the ADI of 0.025 mg/kg bw/day.
So, give me a fucking break dude.
How much myclobutanil is in my duchy?
Your talking out your ass.
Even after knowing all this, seeing a 14 day PHI on apples and grapes, reading the label that says it's only toxic to some aquatic life - I still only treat never flowered clones and then only once so far and then only after trying every other PM treatment I could find on these forums and on PM that strangely only affected a single pheno of a single strain - despite those affected plants rubbing shoulders with plenty of others (it's not my damn environment), and I actually did take the time to explain the whole damn situation to the people I know (how many can
honestly say that).
So anyone who said I'm careless, reckless, clueless, or ignorant can piss off.
